While in group B was statistically significant after two and four weeks after stopping therapy. The result after two weeks in group A was not statistically significant but was statistically significant after four weeks. Results: At the end of four weeks of the study, the response to treatment was as follows: Permethrin (A): Response in 35 (70%) patients and no response in 15 (30%) patients Ivermectin (B): Response in 40 (80%) patients and no response in 10 (20%) patients. These patients were seen regularly every 2 weeks for 4 weeks duration, to re-evaluate for clearance of the disease and to record relapse and any local or systemic side effects.
Ivermectin group (B): Fifty patients applied Ivermectin cream in the same manner of Permethrin. The patients were divided into 2 groups according to the type of therapy: Permethrin group (A): Fifty patients treated by Permethrin cream 5%, 2.5% according to the age applied from the chin to toes at evening and washed after 12 hours and repeated after 7days. History and clinical examination was done for each case to confirm diagnosis. One hundred patients with scabies were enrolled in this work where all socio-demographic data that related to the disease were gained from each patient. It was conducted in the Center of Dermatology, Baghdad Teaching Hospital-Baghdad, Iraq during the period from April 2018 through October 2019. Patients and Methods: This study is a single, blinded, therapeutic comparative trial. Objective: To assess the effectiveness of Ivermectin cream in comparison with Permethrin cream in the treatment of scabies. Ivermectin cream had been used as an effective treatment of scabies. Many therapeutic modalities for scabies are available, but none of them is uniformly effective 100% in treatment of scabies.
#PERMETHRIN CREAM SKIN#
During follow-up, three patients (7.1%) in the group 1 and two patients (4.2%) in the group 2 developed a recurrence or a re-infestation.įive per cent permethrin, when applied as cold cream, on the entire skin surface, once daily for two consecutive days, is more effective than the single application in adult immunocompetent patients with scabies.Background: Scabies is worldwide disease and it is one of the commonest causes of itching. Three patients (7.1%) in the group 1 and 4 patients (10.2%) in the group 2 developed a mild irritant contact dermatitis. Twenty-one patients (61.8%) in the group 1 and 34 patients (87.2%) in the group 2 were considered recovered both clinically and microscopically. The follow-up was 2 months after the end of the treatment. The treatment was repeated in all patients 7-10 days later. No other topical or systemic drugs were allowed, except for a cleanser with chlorhexidine. The cream was left on the skin for 24 hours. The cream was stored in refrigerator and applied cold on the entire skin surface. Clinical diagnosis of scabies was confirmed by microscopical examinations. Topical permethrin, applied once daily, is considered as the most effective treatment in scabies.Įighty-nine adult immunocompetent patients with scabies were treated with 5% permethrin cream: 42 patients were treated with a single application/day (group 1) 47 patients were treated with one application/day for two consecutive days (group 2).
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